Assistant Director of Bioinformatics
Personalized Medicine, Mass General Brigham
Principal Investigator
Satoshi Koyama, MD, PhD
Dr. Koyama studies how human genetic variation contributes to disease risk, molecular mechanisms, and precision prevention across a broad range of human diseases, with a particular focus on cardiometabolic traits. His training in cardiovascular medicine, human genetics, and computational biology grounds the lab's work in rigorous statistical genetics and patient-centered translation.
Academic Appointments & Affiliations
Investigator
Heart and Vascular Institute, Mass General Brigham
Associate Member
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard
Member of the Faculty of Medicine
Harvard Medical School
Education
PhD
Kyoto University
MD
Kobe University
Training
Postdoctoral Fellow
Broad Institute of MIT and Harvard
Postdoctoral Fellow
RIKEN
Cardiology Fellow
Hyogo Prefectural Amagasaki Hospital
Resident Physician
Kobe City General Hospital
Grant Support
Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease
NIH/NHLBI Pathway to Independence Award (R00), R00HL169733 / PI
Extends the genetic understanding of familial hypercholesterolemia and coronary artery disease through whole-genome sequence interpretation.
Past Grant Support
Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease
NIH/NHLBI Pathway to Independence Award (K99), K99HL169733 / PI
Characterized rare coding and non-coding variants in familial hypercholesterolemia and developed integrated risk prediction approaches.
Defining the pathophysiology of coronary artery disease through rare variants and lipid traits
The Uehara Memorial Foundation / PI
Defined how rare variants shape coronary artery disease risk, with a focus on blood lipid traits.
The pathophysiology of coronary artery disease utilizing whole-genome sequencing
JSPS Overseas Research Fellowship, 202160643 / PI
Identified rare effector variants for coronary artery disease using whole-genome sequencing datasets.
Elucidation of the pathophysiology of microRNA in acute heart failure
JSPS Research Fellowship for Young Scientists (DC1), 15J00784 / PI
Described blood microRNA dynamics during acute decompensation in heart failure.
Awards and Honors
Gill Award for Early Contributions to Cardiovascular Research
University of Kentucky Gill Heart & Vascular Institute
Recognized contributions to genetic analysis in atherosclerotic cardiovascular disease.
Academic Leadership
Analytic Lead & PRS Working Group Chair
CARDIoGRAMplusC4D Consortium
Member, GPM Early Career Committee
American Heart Association Council on Genomic and Precision Medicine